HPLC
HPLC and UHPLC are core tools for QC, method development, raw-material and finished-product analysis, purity/impurity determination, and stability testing in the pharmaceutical industry. System choice should be based on application type, pressure/flow range, column type, detector, method-transfer needs, data software, and documentation requirements.
Subcategories
Analytical HPLC
Used for routine QC analysis, method development and transfer, assay, impurity profiling, and stability testing.
Preparative HPLC
Used for separating and purifying compounds at larger-than-analytical scale, fraction collection, method scale-up, and purification in pharmaceutical R&D.
UHPLC / UPLC
Used for faster separations, higher resolution, small-particle-column methods, and higher throughput. "UPLC" is a common commercial name in the market; the site's general taxonomy uses the label UHPLC / UPLC.
Selection Criteria
- Analysis type: QC, R&D, impurity profiling, stability
- Analytical vs. preparative workflow
- Required pressure and flow range
- Particle size and column type
- UV-only vs. other detectors needed
- LC-MS compatibility need
- Existing methods and importance of method transfer
- Throughput and sample count
- Need for fraction collection
- Software, audit trail, and data integrity at the exact configuration level
- Service, parts, consumables, and installed base experience in Iran