B13Pharmaceutical
Karl Fischer Titrator
Karl Fischer titrators precisely determine water/moisture content in raw materials, solvents, APIs, pharmaceutical products, and QC samples. The choice between a volumetric or coulometric system depends on the moisture range, sample type, and test method.
Subcategories
Volumetric Karl Fischer
The volumetric method suits higher moisture ranges (typically from roughly 100 ppm up to high percentages) and works by titrating with Karl Fischer reagent and determining the endpoint.
Coulometric Karl Fischer
The coulometric method suits very low moisture ranges (trace levels up to a few hundred ppm) and measures water via electrochemical generation of iodine in the cell.
Applications
- Pharmaceutical QC
- Raw materials
- API
- Solvents
- Finished products
- R&D
- Moisture / water content determination
Selection Criteria
- Sample moisture range: from trace levels to high percentages
- Sample type: liquid, soluble solid, gas, or oven/headspace-requiring samples
- Test method: volumetric vs. coulometric